Valerian Extract Ze 911 Inhibits Postsynaptic Potentials by Activation of Adenosine A1 Receptors in Rat Cortical Neurons
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چکیده
منابع مشابه
Role of NMDA and non-NMDA receptors in excitatory postsynaptic potentials in rat suprachiasmatic nucleus neurons.
The suprachiasmatic nucleus (SCN) is the site of a putative pacemaking oscillator for the regulation of circadian rhythms in mammals (Nishino et al. 1976; Rusak and Zucker, 1979; Turek, 1985; Mei jer and Rietveld, 1989). The SCN receives visual information from the retinohypothalamic tract (RHT) (Moore, 1973; Millhouse, 1977; Pickard, 1982) and indirectly via the retino-geniculo-supra chiasmati...
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G-protein-coupled receptors (GPCRs) often desensitize during continuous activation, but it is not known whether desensitization is influenced by subcellular location. In hippocampal neurons, activation of adenosine A1 receptors (A1Rs) or GABA(B) receptors on synaptic terminals inhibits neurotransmitter release, whereas activation of the same receptors on cell bodies and dendrites decreases exci...
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Acknowledgements: We are grateful to Drs. Vladimir Parpura and Glenn Stanley for helpful input on a previous draft of the manuscript. We also thank Reno Reyes for technical assistance and the Center for Plant Cell Biology (UCR) for facilitating use of the Leica confocal microscope. Page 1 of 23 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (April 27, 2006). doi:10.1152/ajpregu.00747...
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Supraoptic nucleus (SON) neurons secrete oxytocin or vasopressin in response to various physiological stimuli (e.g., lactation/suckling, dehydration). Released near fenestrated capillaries of the neurohypophysis, these peptides enter the blood and travel to peripheral target organs. The pervasive neuromodulator adenosine, acting at A1 receptors, is an important inhibitory regulator of magnocell...
متن کاملCentral action of a fixed Valerian-hops extract combination (Ze 91019) in freely moving rats.
Due to the electrochemical nature of the communication structure of the brain an intimate relationship between neurotransmitter activity on one side and field potentials (EEG) on the other side have been reported. From this it can be assumed that the electrical activity reflects the net effect of drug action. The influence of increasing doses of Ze 91019 on field potentials in chronically instr...
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ژورنال
عنوان ژورنال: Planta Medica
سال: 2006
ISSN: 0032-0943,1439-0221
DOI: 10.1055/s-2006-947182